High-Intensity Interval Training and Moderate-Intensity Continuous Training Attenuate Oxidative Damage and Promote Myokine Response in the Skeletal Muscle of ApoE KO Mice on High-Fat Diet

The purpose of this study was to investigate the effects high-intensity interval training (HIIT) and moderate-intensity continuous (MICT) on skeletal muscle in Apolipoprotein E knockout (ApoE KO) wild-type (WT) C57BL/6J mice. ApoE KO mice fed with a high-fat diet were randomly allocated into: Control group without exercise (ApoE−/− CON), HIIT HIIT), MICT MICT). Exercise endurance, blood lipid profile, antioxidative capacity, myokine production measured after six weeks interventions. ApoE−/− CON exhibited hyperlipidemia increased oxidative stress, compared WT reduced levels, ROS production, protein carbonyl content muscle, while it enhanced GSH generation potently promoted mRNA expression genes involved irisin BAIBA. Moreover, had significantly lower plasma HDL-C content, MyHC-IIx Vegfa165 EDL, level; but remarkably higher Hadha than those These results demonstrated that both programs effective for by attenuating damage promoting myokines response production. In particular, more beneficial reduce level muscle.